Potential Anti-diabetic Activities from Edible Bird Nest and Its Hydrolysates

Posted on March 12, 2021Categories Chemistry and BiochemistryTags , , , ,   Leave a comment on Potential Anti-diabetic Activities from Edible Bird Nest and Its Hydrolysates

Edible bird’s nest (EBN) is traditionally regarded as a delicacy, with numerous health benefits believed to be sought after in Asia, especially China. The anti-diabetic properties of the EBN and its hydrolysate were discussed in this paper. L6 myotube cells were used to test the ability of EBN hydrolysate to promote glucose absorption in vitro. The anti-diabetic test was carried out in rats in vivo, with fasting blood glucose and oral glucose tolerance being assessed. Metformin, a commercial anti-diabetic drug, … Continue reading “Potential Anti-diabetic Activities from Edible Bird Nest and Its Hydrolysates”

Pimarane Diterpenes from Vietnamese Orthosiphon stamineus Benth. and Their Glucose Uptake Stimulatory and PTP1B Inhibitory Activities

Posted on February 13, 2021Categories Chemistry and BiochemistryTags , , , ,   Leave a comment on Pimarane Diterpenes from Vietnamese Orthosiphon stamineus Benth. and Their Glucose Uptake Stimulatory and PTP1B Inhibitory Activities

From Orthosiphon stamineus Benth, seven pimarane diterpenes (1–7) have been isolated. By isolation by assay-guided. Both isolates had a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazole-4-yl)amino)-d-glucose absorption effect at 5 and 10 μM concentrations in 3T3-L1 adipocytes. Most of them demonstrated potent protein tyrosine phosphatase 1B inhibition with IC50 values ranging from 0.33 to 9.84 μM. In the kinetic analysis, all forms of inhibition were exposed to the forces studied, including mixed-competitive (1), non-competitive (3 and 5), competitive (6) and non-competitive (6) powers (7). The findings … Continue reading “Pimarane Diterpenes from Vietnamese Orthosiphon stamineus Benth. and Their Glucose Uptake Stimulatory and PTP1B Inhibitory Activities”