Study on Synthesis and Biological Activities of Novel 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidines

Posted on May 14, 2021Categories Chemistry and BiochemistryTags , , , , , , , , , ,   Leave a comment on Study on Synthesis and Biological Activities of Novel 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidines

A straightforward method has been developed to synthesize new anti-inflammatory 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidine 5 from aminocyanopyrazole. These compounds were tested for anti-inflammatory, gastroprotective, analgesic, antioxidant, and anticandidal properties. After studying the structure-activity relationships, the compound 6-(4-methoxyphenyl)-3-methyl-1,7-dihydropyrazolo[3,4-d]imidazo[1,2-f]pyrimidine, 5a, was chosen as having the most potent activities. The structures of all novel compounds were determined using IR, 1H NMR, 13C NMR, and HRMS. Author (s) Details Fatma Allouche Laboratory of Medicinal and Environmental Chemistry, Superior Institute of Biotechnology of Sfax, University of … Continue reading “Study on Synthesis and Biological Activities of Novel 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidines”

A Recent Approach: Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model

Posted on March 16, 2021Categories Medicine and MedicalTags , , , ,   Leave a comment on A Recent Approach: Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model

Melatonin is a hormone produced predominantly by the pineal gland and released at night. Its secretion has a circadian pattern, peaking at night. Melatonin is a natural hormone that has a circadian cycle in humans, and its levels rise during the night. Its secretion begins about three months of age and continues to increase during childhood. Melatonin secretion decreases prior to puberty and tends to decline until old age. Melatonin has physiological effects that are mediated by at least four … Continue reading “A Recent Approach: Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model”

Experimental and Theoretical Investigations of Some Tridentate Substituted Salicylaldimines

Posted on March 6, 2021March 6, 2021Categories chemical scienceTags , , ,   Leave a comment on Experimental and Theoretical Investigations of Some Tridentate Substituted Salicylaldimines

(E)-2-((2-hydroxybenzylidene)amino)phenol, (E)-2-((2-hydroxyphenyl)imino)methyl) are five substituted tridentate salicylaldimines. (E)-4-chlorophenol, -4-nitrophenol (E)-2-((2-hydroxyphenyl)imino)methyl)phenol, -2-((2-hydroxyphenyl)imino)methyl)phenol, -2-((2-hydroxyphenyl)imino)methyl)phenol, -2-((2-hydroxyphenyl)imino)methyl)phenol, -2-((2-hydroxypheny (E)-4-bromophenol, -4-methoxyphenol 2-((2-hydroxyphenyl)imino) methyl)-2-((2-hydroxyphenyl)imino) methyl)-2-((2-hydroxyphenyl)imin The elemental analysis, IR, UV, and NMR were used to classify -6-methoxyphenol (1H and 13C). Furthermore, to supplement the experimental results, theoretical calculations using density functional theory were performed on the optimised structures of the salicylaldimines. The compounds’ antibacterial potentials were assessed using the agar-well diffusion process, and their total antioxidant capacities were calculated using the phosphomolybdenum assay. The antibacterial and … Continue reading “Experimental and Theoretical Investigations of Some Tridentate Substituted Salicylaldimines”

Impact of Organic Farming on Agronomic Crops Productivity, Grain Quality and Antioxidant Activity

Posted on February 15, 2021Categories science and technologyTags , , , , , , , ,   Leave a comment on Impact of Organic Farming on Agronomic Crops Productivity, Grain Quality and Antioxidant Activity

The purpose of the study is to understand the effect of chemical or organic fertilizer mechanisms on the physicochemical properties of rice grain, starch pasting properties and antioxidant characteristics. In the same way, the development improvements in the finger millet crop are brought on by some of the indigenous liquid organic manure. For rice, a 2-year study was conducted on common Japonica cultivars, i.e., Kaohsiung No. 139 and Taikeng No.16, which were grown in Taiwan twice a year. The findings … Continue reading “Impact of Organic Farming on Agronomic Crops Productivity, Grain Quality and Antioxidant Activity”

Delphinol®, a Delphinidin-Enriched Maqui Berry Extract, Improves Bone Metabolism through NF-kB Inactivation and Protects against Bone Loss in Osteopenic Mouse Models

Posted on January 14, 2021Categories Medicine and MedicalTags , , , , , , , ,   Leave a comment on Delphinol®, a Delphinidin-Enriched Maqui Berry Extract, Improves Bone Metabolism through NF-kB Inactivation and Protects against Bone Loss in Osteopenic Mouse Models

Delphinidin, one of the most abundant anthocyanidins found in vegetables and berry fruits, has been reported to inhibit the formation of osteoclasts from RAW264.7 cells and prevent bone loss in osteoporosis mouse models. We investigated whether a delphinidin glycoside-enriched maqui berry extract (MBE, Delphinol®) exhibits beneficial effects on bone metabolism both in vitro and in vivo to further support the bone protective effects of delphinidin. By upregulating bone morphogenetic protein 2 (Bmp2), runt-related transcription factor 2 (Runx2), osterix (Osx), osteocalcin … Continue reading “Delphinol®, a Delphinidin-Enriched Maqui Berry Extract, Improves Bone Metabolism through NF-kB Inactivation and Protects against Bone Loss in Osteopenic Mouse Models”

Assessing the In Vitro Antioxidant Activity of Withania somnifera Root

Posted on December 31, 2020Categories chemical scienceTags , , , ,   Leave a comment on Assessing the In Vitro Antioxidant Activity of Withania somnifera Root

Due to their structural sophistication, chemical diversity, lack of significant toxic effects and a wide range of antimicrobial activity, conventional herbal medicines are new therapeutic candidates. It can be found in the Mediterranean, Africa, and India. Objective: To test and compare the in vitro antioxidant activity of the indigenous Withania somnifera methanol extract to that of the imported root extract. Methods: ABTS•+ radical cation de-colorization assay, DPPH• radical scavenging activity, radical scavenging activity of nitric oxide, Fe2+ chelating activity assay, … Continue reading “Assessing the In Vitro Antioxidant Activity of Withania somnifera Root”

A Comparative Study of in vivo Plant and in vitro Callus Extracts of Coccinia indica (W. and A)

Posted on November 6, 2020Categories BiotechnologyTags , , , , ,   Leave a comment on A Comparative Study of in vivo Plant and in vitro Callus Extracts of Coccinia indica (W. and A)

An attempt was made in the present study to evaluate the phytochemical, antimicrobial , antioxidant and alpha-amylase inhibitory activity of leaf extracts of Coccinia indica (W. and A) using four solvents and to compare them with callous extracts. The leaf explants of C. were initiated by Callus. Indica with 90 % efficiency using BAP (1 mg / l) + NAA (0.2 mg / l) supplemented with MS medium. Successive C method of extraction. Indica was found to be an effective … Continue reading “A Comparative Study of in vivo Plant and in vitro Callus Extracts of Coccinia indica (W. and A)”

Investigation on in vitro Evaluation of Antioxidant and Anti-inflammatory Properties of Methanol and Dichloromethane Extracts of the Leaf of Globimetula oreophila

Posted on October 14, 2020Categories ChemistryTags , , , ,   Leave a comment on Investigation on in vitro Evaluation of Antioxidant and Anti-inflammatory Properties of Methanol and Dichloromethane Extracts of the Leaf of Globimetula oreophila

Objectives: The purpose of the study was to investigate the antioxidant and membrane stabilising potential of Globimetula oreophila leaves in order to provide scientific support for the plant ‘s existing ethnomedicinal or traditional uses. Methodology: The research included the collection, identification, drying, spraying, extraction and fractionation of dried G leaf extracts. Oreophila. Oreophil. In the assays (2,2-diphenyl-1-picrylhydrazyl hydrate, nitric oxide, total antioxidant potential and ferric reducing antioxidant power), the anti-inflammatory and antioxidant activities of the extracts and fractions were evaluated … Continue reading “Investigation on in vitro Evaluation of Antioxidant and Anti-inflammatory Properties of Methanol and Dichloromethane Extracts of the Leaf of Globimetula oreophila”

Study on Antioxidant and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos

Posted on September 17, 2020Categories ChemistryTags , , , ,   Leave a comment on Study on Antioxidant and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos

In this study, we evaluated the effects of xanthone crude extract (XCE) and α-mangostin (α-MG) on normoxic and hypoxic human hepatocellular carcinoma (HepG2) cells and their toxicity towards zebrafish embryos. XCE was isolated using a mixture of acetone and water (80:20) and verified via high performance liquid chromatography (HPLC). The antioxidant activities of both XCE and α-MG compounds were determined where α-MG had the lowest antioxidant activities followed by XCE and ascorbic acid, (IC50 = >50 μg/mL, 8.25 ± 0.2, … Continue reading “Study on Antioxidant and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos”

Antimicrobial and Free Radical Scavenging Effects of Cow Urines from different Geographical Regions of Nepal

Posted on July 28, 2020Categories biological scienceTags , , , ,   Leave a comment on Antimicrobial and Free Radical Scavenging Effects of Cow Urines from different Geographical Regions of Nepal

Background: Cow urine has been extensively used as healing or additive agents in different parts of Nepal, mainly to treat infections, cuts, burns, etc. Cow urine has been considered as revered and holy water and used in many rituals and worshipping purposes. Along with therapeutic and rituals ceremony cow urine is also used in cleansing and disinfecting the houses. Objective: The aim of the study was to examine the in-vitro antioxidant and antibacterial activity of cow urine from different geographical … Continue reading “Antimicrobial and Free Radical Scavenging Effects of Cow Urines from different Geographical Regions of Nepal”