Focusing on Organocatalytic Asymmetric Michael Addition of Ketones to α, β-unsaturated Nitro Compounds

Posted on November 4, 2020Categories chemical scienceTags , , , ,   Leave a comment on Focusing on Organocatalytic Asymmetric Michael Addition of Ketones to α, β-unsaturated Nitro Compounds

An “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative” organic catalyst was formed as a chiral bifunctional organocatalyst and applied to transβ-nitroalkene compounds under neutral conditions for asymmetric Michael additions of aromatic ketones. High chemical yield and enantioselectivity (ee) are given by the isopropyl-substituted neutral thiourea catalyst (up to 96 percent yield, 98 percent ee). Transformation to highly enantioselective products established the synthetic utility of the present catalytic asymmetric Michael addition. As a muscle relaxant, Baclofen is used, while Phenibut is a sleep inducer. These … Continue reading “Focusing on Organocatalytic Asymmetric Michael Addition of Ketones to α, β-unsaturated Nitro Compounds”