A New Convenient Synthesis of Tetra Substituted Pyrimidines and Their Antimicrobial Screening Report

Posted on September 17, 2020Categories ChemistryTags , , ,   Leave a comment on A New Convenient Synthesis of Tetra Substituted Pyrimidines and Their Antimicrobial Screening Report

An efficient and novel strategy has been developed using potassium carbonate as catalyst for synthesis of 4-amino-2-methyl-6-(methylthio)pyrimidine-5-carbonitrile (3) by condensing acetamidine hydrochloride (1) with bis(methylthio)methylene malononitrile (2) in DMF. Compound (3) is susceptible to nucleophilic substitution reaction due to presence of methylthio group at sixth position, which is replaced by different nucleophiles such as substituted anilines, phenols, hetryl amines and compounds containing active methylene group to afford 6-substituted derivatives of 4-amino-2-methyl- 6-(methylthio)pyrimidine-5-carbonitriles (4a-7d). All newly prepared compounds were characterized by … Continue reading “A New Convenient Synthesis of Tetra Substituted Pyrimidines and Their Antimicrobial Screening Report”