An Overview of Bacterial Superantigen Toxins, CD28, and Drug Development

Posted on September 17, 2020Categories ChemistryTags , , , , , ,   Leave a comment on An Overview of Bacterial Superantigen Toxins, CD28, and Drug Development

Acute toxic shock is induced by superantigen toxins, a diverse set of proteins secreted by Grampositive staphylococcal and streptococcal bacterial strains that overstimulate the inflammatory response by orders of magnitude. The need to protect from superantigen toxins led to our discovery that in addition to the well-known MHC class II and T cell receptors, the principal costimulatory receptor, CD28, and its constitutively expressed coligand, B7-2 (CD86), previously thought to have only costimulatory function, are actually critical superantigen receptors. Binding of … Continue reading “An Overview of Bacterial Superantigen Toxins, CD28, and Drug Development”