Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on Tcells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response by orders of…
Tag: CD28 receptor
An Overview of Bacterial Superantigen Toxins, CD28, and Drug Development
Acute toxic shock is induced by superantigen toxins, a diverse set of proteins secreted by Grampositive staphylococcal and streptococcal bacterial strains that overstimulate the inflammatory response by orders of magnitude. The need…