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Tag: CD28 receptor

A Review on CD28: Direct and Critical Receptor for Superantigen Toxins

Posted on September 17, 2020 by Editor JournalGazett

Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on Tcells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response by orders of…

An Overview of Bacterial Superantigen Toxins, CD28, and Drug Development

Posted on September 17, 2020 by Editor JournalGazett

Acute toxic shock is induced by superantigen toxins, a diverse set of proteins secreted by Grampositive staphylococcal and streptococcal bacterial strains that overstimulate the inflammatory response by orders of magnitude. The need…

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