An Advanced Study on Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications

Posted on February 9, 2021Categories chemical scienceTags , , , ,   Leave a comment on An Advanced Study on Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications

Using cyclic, differential pulse and square wave voltammetric techniques for the determination of trace-level chalcone at a glassy carbon electrode, a simple and rapid method was developed. Two anodic peaks at about 0.514 V and 1.478 V and a cathodic peak at about −0.689 V could be generated by Chalcone. The differential pulse voltammerty has a strong linear response in the range of 0.2 – 10 μM with a detection limit of 0.18 μM compared to square wave voltammetry. The … Continue reading “An Advanced Study on Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications”

Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products

Posted on November 4, 2020Categories chemical scienceTags , , , , , , , ,   Leave a comment on Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products

The present study seeks to investigate the synthesis and structural characteristics of derivatives of Indanone, Tetralone and Naphthone. Via Claisen condensations, arylhydrazine condensations, BakerVenkataraman rearrangements, Claisen-Schmidt reactions, selective fluorinations and trifluoroacetylations in yields ranging from 22-92 percent, indanone, tetralone and naphthone derivatives and fused-ring heterocycles were prepared. Regiochemistry and stereochemistry observed in these products and their usefulness as scaffolds for the preparation of heterocyclic derivatives are of particular interest. Unusual changes such as a novel one-pot, dual trifluoroacetylation, trifluoroacetylnaphthone synthesis … Continue reading “Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products”

Scientific Overview of Synthesis and Antimicrobial Evaluation of Novel 3-(thiophen-2-yl) -Pyrazoline-5-yl Derivatives

Posted on August 4, 2020Categories Medicine and PharmacyTags , ,   Leave a comment on Scientific Overview of Synthesis and Antimicrobial Evaluation of Novel 3-(thiophen-2-yl) -Pyrazoline-5-yl Derivatives

Ten derivatives of N1 substituted/unsubstituted 5-(4-chlorophenyl)-3-(2-thienyl) pyrazoline were synthesised from chalcone-like intermediate and substituted phenyl hydrazines, hydrazine hydrate, and semi/thiosemicarbazide. The chemical structure of compounds was confirmed by means of IR, 1 HNMR, mass spectroscopy, and elemental analysis. The antimicrobial activities (antibacterial and antifungal activities) of the synthesized compounds were evaluated against Staphylococcus aureus, Staphylococcus faecalis, Escherichia coli, Salmonella typhi, and Candida albicans by agar diffusion cup plate method. Compound IId (5-[(4-chlorophenyl)-1-(4-methoxyphenyl)]-3-thiophen-2-yl)-4,5- dihydro-2-pyrazoline), IIg (5-(4-chlorophenyl)-1-(2-methylphenyl)-3-(thiophen-2-yl)-4,5-dihydro-2- pyrazoline) showed very good activity. … Continue reading “Scientific Overview of Synthesis and Antimicrobial Evaluation of Novel 3-(thiophen-2-yl) -Pyrazoline-5-yl Derivatives”