Critical Study on Tetramethylpyrazine and Paeoniflorin Inhibit Oxidized LDL-induced Angiogenesis in Human Umbilical Vein Endothelial Cells via VEGF and Notch Pathways

Posted on August 4, 2020Categories Medicine and PharmacyTags , , , , ,   Leave a comment on Critical Study on Tetramethylpyrazine and Paeoniflorin Inhibit Oxidized LDL-induced Angiogenesis in Human Umbilical Vein Endothelial Cells via VEGF and Notch Pathways

Atherosclerotic plaque angiogenesis is key factor inplaque instability and vulnerability, and low concentrations of oxidized low density lipoprotein (ox-LDL)promote the in vitro angiogenesis of endothelial cells and play an important role inplaque angiogenesis. Ligusticum chuanxiong Hort. and Radix Paeoniae Rubra herb pair in Chinese medicine obtainsthe optimum therapeutic efficacy in atherosclerosis, and their major active ingredientste tramethylpyrazine (TMP) and paeoniflorin (PF) are reported to alleviate atherosclerosis. The aim of this study was to investigate the effects of TMP and PF … Continue reading “Critical Study on Tetramethylpyrazine and Paeoniflorin Inhibit Oxidized LDL-induced Angiogenesis in Human Umbilical Vein Endothelial Cells via VEGF and Notch Pathways”